Abstract: With the strengthening of human engineering activities, the incidence of karst ground collapse in Huadu District of Guangzhou has increased year by year, so it is very important to evaluate the risk zones of karst ground collapse. By identifying and judging the karst ground collapse factors in Huadu District, 9 indexes including karst development degree, karst water inflow from a single well, karst groundwater level and dynamic change, karst water level drop, lithologic structure of overlying soil layer, thickness of overlying soil layer, ground geomorphic characteristics, building density and the point of karst ground collapse have been selected. The risk assessment model of karst ground collapse in Huadu District was established. Taking the matrix unit of karst ground collapse in Huadu District as an example, the risk zoning of karst ground collapse is carried out, and it is divided into three levels: large risk area, medium risk area and small risk area. The results show that the risk areas in the study area account for 44.2% of the karst development areas, most of which are karst subsidence areas. In the study area, the medium risk area accounts for 5.5% of the karst development area and belongs to the quaternary covered karst area, which is distributed in the southern and northwestern parts of the study area. The dangerous area accounts for 50.3% of the karst development area in the study area, and its distribution range is mainly covered karst area in the north. The research results can provide important reference value for geological disaster prevention and reduction in urban development areas in China.