Abstract: Land subsidence in Nansha District has affected urban development and the safety of people’s lives and properties. In order to formulate scientific and effective measures to prevent the further development of land subsidence, this paper summarizes and analyzes the distribution characteristics of land subsidence based on InSAR monitoring data and level monitoring data, the surface deformation is mostly severe settlement in a small and local area. On this basis, for 6 areas with subsidence. The mechanism model is used to quantitatively estimate the amount of land subsidence caused by each factor and its proportion. The subsidence caused by the compressible soil layer was 34.43−96.97 mm/a, the proportion is between 37.07% and 75.67%, and the largest influence proportions of groundwater level and ground load are 26.28% and 52.40%. And through research and analysis of the main factors and impact of land subsidence, this paper provide a scientific basis for scientific prevention and control of land subsidence in this area.