Abstract: Assessment indicator system of comprehensive earthquake vulnerability in cities is established, which is aimed to reduce the vulnerability in cities, for the purpose to conduct scientific evaluation on earthquake vulnerability.The system is based on pressure-state-response (PSR) model framework, respectively the indicator is 7, 13 and 8 items. The assessment model of comprehensive earthquake vulnerability in cities, based on cloud model, is brought up by determine the weights of each indicator through the method of entropy weight. At the same time, radar maps are applied to analyse the relativity of comprehensive vulnerability in different districts in cities. An evaluation on comprehensive vulnerability after earthquake damage in center districts in Lanzhou was conducted by application of above mentioned methods. The result shows that comprehensive vulnerability in Lanzhou deviates to level Ⅲ with a medium vulnerability. Honggu and Anning Districts suffer from higher vulnerability while Chengguan and Qilihe Districts bear the lower. In addition, economic elements have a rather prominent impact on the vulnerability in the various districts. Reinforcing management and construction in more vulnerable districts can improve their capacity in the act of earthquake prevention and disaster reduction.