Abstract: Taking the investigation of the mined-out area of gypsum mine in Mengxi-Huazhong railway Jingmen-Yueyang section as an example, this paper introduces the comprehensive survey method of the mined-out area by the combination of remote sensing interpretation, investigation and visit and exploration verification. In view of the problems of railway route selection through goaf, the working idea of goaf survey is put forward, and the remote sensing interpretation method of goaf based on satellite photograph, aerial photograph and multi-temporal analysis is expounded. This paper puts forward the problems that should be paid attention to in the investigation and visit of goaf and how to carry out comprehensive analysis. It is also proposed that the exploration verification method should be reasonably selected according to the regional geological conditions, the development characteristics of the goaf, the applicability of exploration methods, site conditions and so on. Finally, the comprehensive survey of goaf in Jinling and Baoan gypsum mines is introduced, which can provide reference for similar goaf investigation.