Abstract: In order to explore the practical role of highway slope automatic monitoring system based on GNSS monitoring station, this paper studies the K69 + 080 section of YQTJ5 section of Chongqing Banan Qijiang Expressway. Firstly, based on LZMR02-GNSS receiver and FS-YL rain gauge, Beidou + safety monitoring cloud platform is independently developed, which can manage and analyze the GNSS surface displacement monitoring stations and deep displacement monitoring holes arranged on site in real time. The monitoring results show that the slope has local collapse and cracking and other unstable phenomena, and early warning is sent to relevant departments and units. Then, the residual sliding force of the slope is calculated based on the transfer coefficient method, and the numerical simulation is carried out by using Geo5 finite element software. The results verify the accuracy of the monitoring system. Therefore, the establishment of highway slope automatic monitoring system can not only solve the shortcomings of conventional manual monitoring of slope, but also ensure the timeliness of monitoring data, which provides a certain reference value for future intelligent monitoring of slope.